Zonulin

Definition

Zonulin is a protein within the body that regulates the permeability of the gut lining. When activated, this protein signals the intestines to open up the spaces between its cells to allow larger-than-normal molecules through the intestinal walls into the blood stream.

Health considerations

This protein has been implicated in being partially responsible for diseases such as Type 1 Diabetes, Type 2 Diabetes, Dermatitis Herpetiformis and Celiac Disease. Thus far, gluten and intestinal bacteria (beneficial and harmful strains) have been shown to affect zonulin activity, causing increased inflammation and immune responses in the gut.

References

Tissue Barriers
Molecular and Cellular Biochemistry
Anais Brasileiros de Dermatologia